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Some patients may benefit from slower dose escalation or temporary dose reduction of their GLP-1 medication if constipation becomes problematic, though this should only occur under medical supervision

Additionally, the PI3K pathway is stimulated by suppression of a negative regulator, phosphatase and tensin homologue (PTEN) (104)

The decline is often irregular, with good days and bad days rather than a smooth improvement curve

J Neuroophthalmol, 2018

It also serves a dual purpose by improving hyperpigmentation around the eyes thanks to the addition of phenylethyl resorcinol, an ingredient that helps support balanced melanin production